Printing personalised medicines on demand (PrintMed)

PN 1A-5

Project description

Methods of pharmaceutical manufacturing are likely to change dramatically over the coming years. Driven by the knowledge and technology that is already available in other sectors, the processing of drugs into dosage units can be transformed into a “pharmacy-on-demand” process that allows individual dosing, based on criteria relevant for the effective use of the drug in an individual patient. One approach to achieve “pharmacy-on-demand” is the use of inkjet printing technology to deliver an exact dose of drugs on porous substrates. This proof-of-concept project is based on knowledge we acquired during my ERC AdG project on processes of printing on paper using inkjet printing. We will demonstrate the viability of "printing" highly accurate amounts of a solution containing levothyroxine, prescribed for hypothyroidism, onto a porous tablet.

Modelling tools will be combined with cutting-edge characterization technologies to push the understanding of printed drug-containing inklike solutions in porous dosage unit matrices. This project will transfer pharmaceutical formulation and product design of individual dosage forms with the use of inkjet printing technique to the pharmaceutical community. They can work on clinical approval tests of the developed oral dosage forms and move these products toward clinical use. The patients will benefit directly from development of this production technique, because a much more effective and targeted medication can be provided. The next step will be the development of the inkjet printing technique for other personalized medicines such as pain killers for children, hormones, biomacromolecules, psychoactive and anticancer drugs. Individually-dosed medicines will allow for substantial decrease of drug waste and thus overall reduction of medical expenses.

Project information

Project title Printing personalised medicines on demand (PrintMed)
Project leader Majid Hassanizadeh
Project duration November 2020 - April 2022
Project number PN 1A-5

Publications PN 1A-5

  1. 2022

    1. L. Yan et al., “A quantitative study of salinity effect on water diffusion in n-alkane phases: From pore-scale experiments to molecular dynamic simulation,” Fuel, vol. 324, p. 124716, Sep. 2022, doi: 10.1016/j.fuel.2022.124716.
    2. N. Seetha and S. M. Hassanizadeh, “A two-way coupled model for the co-transport of two different colloids in porous media,” Journal of Contaminant Hydrology, vol. 244, p. 103922, 2022, doi: 10.1016/j.jconhyd.2021.103922.
    3. L. Boumaiza et al., “Predicting Vertical LNAPL Distribution in the Subsurface under the Fluctuating Water Table Effect,” Groundwater Monitoring & Remediation, 2022, doi: 10.1111/gwmr.12497.
    4. S. Aseyednezhad, L. Yan, S. M. Hassanizadeh, and A. Raoof, “An accurate reduced-dimension numerical model for evolution of electrical potential and ionic concentration distributions in a nano-scale thin aqueous film,” Advances in Water Resources, vol. 159, pp. 1--9, 2022, doi: 10.1016/j.advwatres.2021.104058.
    5. S. V. Dastjerdi, N. Karadimitriou, S. M. Hassanizadeh, and H. Steeb, “Experimental Evaluation of Fluid Connectivity in Two-Phase Flow in Porous Media During Drainage,” Water Resources Research, vol. 58, no. 11, Art. no. 11, Nov. 2022, doi: 10.1029/2022wr033451.
    6. Y. S. R. Krishna, N. Seetha, and S. M. Hassanizadeh, “Experimental and numerical investigation of the effect of temporal variation in ionic strength on colloid retention and remobilization in saturated porous media,” Journal of Contaminant Hydrology, vol. 251, p. 104079, Dec. 2022, doi: 10.1016/j.jconhyd.2022.104079.
    7. R. Cui, S. M. Hassanizadeh, and S. Sun, “Pore-network modeling of flow in shale nanopores : Network structure, flow principles, and computational algorithms,” Earth science reviews, vol. 234, no. November, Art. no. November, 2022, doi: 10.1016/j.earscirev.2022.104203.
    8. M. S. Walczak, H. Erfani, N. K. Karadimitriou, I. Zarikos, S. M. Hassanizadeh, and V. Niasar, “Experimental Analysis of Mass Exchange Across a Heterogeneity Interface: Role of Counter-Current Transport and Non-Linear Diffusion,” Water Resources Research, vol. 58, no. 6, Art. no. 6, Jun. 2022, doi: 10.1029/2021wr030426.

  2. 2021

    1. L. Zhuang, S. M. Hassanizadeh, D. Bhatt, and C. van Duijn, “Spontaneous Imbibition and Drainage of Water in a Thin Porous Layer: Experiments and Modeling,” Transport in Porous Media, vol. 139, no. 2, Art. no. 2, 2021, doi: 10.1007/s11242-021-01670-7.

Data and software publications PN 1A-5

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