10/28

October 28, 2019, 2:00 p.m. (CET)

GS SimTech Milestone Presentation: Aaron Krämer

Time
October 28, 2019, 2:00 p.m. (CET)
 
Universität Stuttgart, Campus Vaihingen, Room 7.122, Pfaffenwaldring 57

The next milestone presentation of the GS SimTech will be held by Aaron Krämer from the Institute of Applied Analysis and Numerical Simulation:

What: High Performance Computing techniques for detailed Simulations of a Multi-Scale Sceletal Muscle Model
Advisor: Prof. Dominik Göddeke

Note: The milestone presentation is designed to allow reflection on interim work results and for establishing the individual PhD students‘ remaining program of work in consultation with their respective supervisors.

Abstract

Within the Digital Human project (DiHu) we  pursue to bring detailed bio-mechanical simulation of skeletal muscle from basic research to clinical settings. The underlying model of a three-dimensional mechanical macro scale part in which active force generation occurs due to excitation-contraction processes on a micro scale.
These micro-scale bio-chemical processes are typically described, based on Hodgkin-Huxley-type models. They model changes of the local transmembrane voltage, $V_m$ , of a muscle fibre as a consequence of ion currents, induced by chemical imbalances and are represented by a system of ODEs. Due to cross bridge cycling (inflating the system of ODEs) this leads to forces on a micro scale. Total ODE systems may have up to 100 unknowns. The numerical challenge in the DiHu project lies in a massive size of DOFs (~ 1M fibres /muscle, 1-2k systems of ODEs /fibre) accompanied with stiff micro scale processes and the necessity of bi-directional coupling in between all model parts.

SimTech organizes a variety of events and meetings such as the annual status seminar, seminars on different topics and public events. Here you get all the necessary information about those events.


November 2020

October 2020

August 2020

July 2020

June 2020

May 2020

March 2020

February 2020

January 2020

December 2019

November 2019

October 2019

September 2019

July 2019

June 2019

May 2019

June 2019

November 2019

To the top of the page