Prof. Dr. rer. nat.

Nicole Radde

Board of Directors, Principal Investigator (EXC), Fellow (SC), Coordinator PN 2
Institute for Systems Theory and Automatic Control

Contact

+49 711 685-67729

Website

Pfaffenwaldring 9
70569 Stuttgart
Germany
Room: 2.243

Subject

  • Dynamic modeling of intracellular regulation processes
  • Statistical sampling-based approaches for parameter estimation and uncertainty quantification
  • Analysis methods for intracellular regulation networks based on their network topology

Selected Publications

  1. A. Jensch, C. Thomaseth, and N. Radde. “Sampling-based Bayesian approaches reveal the importance of quasi-bistable behavior in cellular decision processes on the example of the MAPK signaling pathway”. In: BMC Systems Biology 11.11 (2017).
  2. E. Geissen, J. Hasenauer, S. Heinrich, S. Hauf, F. J. Theis, and N. Radde. “MEMO – multi-experiment mixture model analysis of censored data”. In: Bioinformatics 32.16 (2016), pp. 2464–2472.
  3. P. Weber, M. Hornjik, M. A. Olayioye, A. Hausser, and N. Radde. “A computational model of PKD and CERT interactions at the trans-Golgi network of mammalian cells”. In: BMC Systems Biology 9.9 (2015).
  4. A. Kramer, B. Calderhead, and N. Radde. “Hamiltonian Monte Carlo Methods for Efficient Parameter Estimation in Steady State Dynamical Systems”. In: BMC Bioinformatics 15.253 (2014).
  5. A. Kramer, V. Stathopoulos, M. Girolami, and N. Radde. “MCMC_CLIB: An advanced MCMC sampling package for ODE models”. In: Bioinformatics 30.20 (2014), pp. 2991–2992.
  6. S. Heinrich, E. Geissen, J. Kamenz, S. Trautmann, C. Widmer, P. Drewe, M. Knop, N. Radde, J. Hasenauer, and S. Hauf. “Determinants of robustness in spindle assembly checkpoint signalling”. In: Nature Cell Biology 15.11 (2013), pp. 1328–1339.
  7. C. Thomaseth, P. Weber, T. Hamm, K. Kashima, and N. Radde. “Modeling sphingomyelin synthase 1 driven conversion of ceramide to sphingomyelin at the Golgi apparatus can be explained by a positive feedback mechanism”. In: Journal of Theoretical Biology 337 (2013), pp. 174–180.
  8. N. Radde. “Analyzing fixed points of intracellular regulation networks with interrelated feedback topology”. In: BMC Systems Biology 6.57 (2012).
  9. P. Weber, C. Dingler, A. Kramer, and N. Radde. “Trajectory-oriented Bayesian experiment design versus Fisher A-optimal design: an in depth comparison study”. In: Bioinformatics 28.18 (2012), pp. i535–i541.
  10. N. Radde. “Fixed point characterization of biological networks with complex graph topology”. In: Bioinformatics 26.22 (2010), pp. 2874–2880.

Working Experience

  • since 2017 Equal Opportunity Commissioner of the University of Stuttgart
  • since 2015 Professor for Systems Theory in Systems Biology, Institute for Systems Theory and Automatic Control and Stuttgart Centre for Simulation Science, University of Stuttgart
  • 2011, 2013 Parental leaves
  • 2008–2014 SimTech Junior Professor for Systems Theory in Systems Biology, Institute for Systems Theory and Automatic Control, University of Stuttgart
  • 2007–2008 Postdoctoral researcher at the Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig
  • 2003–2007 Scientific assistant at the Center for Applied Computer Science, University of Cologne

 

Academic Studies and Degrees

  • 2007 Dr.rer.nat., Faculty of Mathematics and Natural Sciences, University of Cologne
  • 2002 “Erstes Staatsexamen” for high school teaching (“Gymnasium”) in the subjects Physics and Mathematics, TU Darmstadt
  • 2002 Diploma in Physics, TU Darmstadt
  • 1998–2002 Study of Physics, TU Darmstadt
  • 1996–2002 Study of Physics and Mathematics on teaching profession, TU Darmstadt
  • 2012 Invited participation at the Dagstuhl Seminar “Symbolic Methods for Chemical Reaction Networks”, Nov 11–16 2012, Schloss Dagstuhl, Wadern
  • 2012 Scholarship of the Alexander von Humboldt Foundation for participation at the “3. Brazilian-German Frontiers of Science and Technology Symposium”, Brasilia, Brasilien, Nov 8–11 2012.
  • 2009 Best Paper Award, 9th International Conference on Computing Anticipatory Systems (Casys09), Liege, Belgium, August 2009.
  • 2005 DAAD Scholarship for a 2 month research stay at the “Bioscience Division”, Los Alamos National Laboratories, Los Alamos, NM, USA, 9/2005–10/2005.
  • Member of the reviewer panel of the funding initative “Life? – A fresh scientific approach to the basic principles of life”, Volkswagen foundation (2016)
  • Member of the working committee “Lehre” of the expert commission Ingenieurwissenschaften @BW2025 of the BW Ministry of Science, Research and Arts (2015)
  • Chair and local organization of the Physics School “The Physics behind Systems Biology”, Jacobs University Bremen, Wilhelm und Else Heraeus Foundation (2015)
  • Jury member “Add-On Fellowship for Interdisc. Science”, Joachim-Herz-Foundation (since 2015)
  • Jury member “Deutschlandstipendium”, Fed. Ministry of Education and Research (2014–2016)
  • Member of the working committee “Qualitätssicherungskonzepte für den echten Tenure Track” of the BW Ministry of Science, Research and Arts (2014)
  • PI and member of the Advisory Board EXC 310 “Simulation Technology” (since 2012)
  • Chair and local organization of the GmdS/IBS workshop on “Statistical and dynamical models in biology and medicine”, University of Stuttgart (2012)
  • Member of the GmdS/IBS working group “Statistical methods in Bioinformatics” (since 2010)
  • 2010–2013: Member of the managing committee of the working group
  • since 2009: Member of the Board of Directors of the Stuttgart Research Center Systems Biology (SRCSB), formerly Center Systems Biology (CSB)
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