PN 7: Dynamics and modelling in systems biology
Coordinators: Prof. Dr.-Ing. Frank Allgöwer, Prof. Dr. rer. nat. Guido Schneider
Research Areas: C, D
Number of projects: 5 + 2 JP seed projects
Systems biology is a significant paradigm shift in the life sciences with potentially far-reaching benefits for society. In particular medicine, pharmacy, process industry, and agriculture may profit tremendously from the implementation of systems biology in the life sciences. In that respect, Project Network 7 aims at achieving a shift from classical descriptive biology towards a systems-biologically dominated view on living systems and in particular on developing methods, tools and understanding in how far modern simulation technology can contribute to these advances. To achieve this aim the research performed in Project Network 7 focuses on two aspects:
- Adjustment of established and newly developed methods in simulation technology for the application to problems in systems biology, in order to achieve a quantitative dynamical description of biological processes and to allow the prediction of their behavior.
- Development of new methods in simulation technology that are inspired by new problem classes and challenges occurring in systems biology research.
With these goals, we strive to establish a tight interconnection between simulation technology methods and systems biology research which is able to support the firm integration of systems biology in the life sciences.
All projects in Project Network 7 at a glance:
7-1
Analysing biological systems with interlocked feedback circuits
Project Coordinator: JP Dr. rer. nat. Nicole Radde
Research Associate: Dipl.-Phys. Andrei Kramer
Institute for Systems Theory and Automatic Control
Project abstract | Status report
7-2
Comparison of modelling in systems biology
Project Coordinator: Prof. Dr. rer. nat. Guido Schneider
Research Associate: Dipl.-Math. Markus Daub
Institute for Analysis, Dynamics und Modelling
More about the project | Project abstract | Status report
7-3
Dynamical behaviour of complex systems
Project Coordinator: Prof. Dr.-Ing. Frank Allgöwer
Research Associate: Dipl.-Ing. Jan Hasenauer
Institute for Systems Theory and Automatic Control
More about the project | Project abstract | Status report
7-4
Modelling and simulation of TNF-receptor clustering
Project Coordinators: Prof. Dr. rer. nat. Peter Scheurich, Dr. rer. nat. Christina Surulescu
Research Associates: Dipl.-Biol. Simon Neumann, Dipl.-Math.techn. Christian Winkel
Institute of Cell Biology and Immunology, Institute for Applied Analysis and Numerical Simulation
More about the project | Project abstract | Status report
7-5
Project Parameter Identification: Efficient methods for Parameter Identification in Differential Equation Models
Project Coordinators: Prof. Dr. Barbara Kaltenbacher, JP Dr. rer. nat. Nicole Radde, Prof. Dr. rer. nat. Barbara Wohlmuth
Research Associate: Dipl.-Math. Jonas Offtermatt
Institute of Stochastics and Applications, Institute for Systems Theory and Automatic Control, Institute for Applied Analysis and Numerical Simulation
More about the project | Project abstract | Status report
7-6
Investigation of possible oligomeric structures of tumor necrosis factor with its receptors TNF-R1 and TNF-R2 and estimation of the stability of these structures (JP seed project)
Project Coordinator: JP Dr. rer. nat. Johannes Kästner
Institute for Theoretical Chemistry
More about the project | Project abstract
7-7
Modeling regulation mechanisms in secretory pathways: A data- and knowledge-based modeling approach for regulation mechanisms in secretory pathways (JP seed project)
Project Coordinator: JP Dr. rer. nat. Nicole Radde
Research Associate: Dipl.-Ing. Patrick Weber
Institute for Systems Theory and Automatic Control
More about the project | Project abstract